Artemisinin and Nitric Oxide: Mechanisms and Implications in by Qing-Ping Zeng

By Qing-Ping Zeng

This publication discusses either the helpful and damaging features of NO in biology and drugs, and in addition introduces the rising discovery of artemisinin in antitumor, antibacterial an infection, anti-inflammation, and antiaging contexts. In 1992 nitric oxide (NO) was once voted “Molecule of the yr” via technology journal, and the invention of its physiological roles has resulted in Nobel Prize-winning paintings in neuroscience, body structure and immunology. The booklet explains why we should always keep a steady-state NO point that's derived from neuronal or epithelial NO synthase, and steer clear of the super excessive NO point caused by inducible NO synthase. The ebook bargains a beneficial source for clinical chemists, clinicians, biologists and all these attracted to wellbeing and fitness and disease.

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Extra info for Artemisinin and Nitric Oxide: Mechanisms and Implications in Disease and Health

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PLoS One: e9582 Webb DJ, Freestone S, Allen MJ, Muirhead GJ (1999) Sildenafil citrate and blood-pressure-lowering drugs: results of drug interaction studies with an organic nitrate and a calcium antagonist. Am J Cardiol 83:21C–28C Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, Rashid R, Miall P, Deanfield J, Benjamin N, MacAllister R, Hobbs AJ, Ahluwalia A (2008) Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite.

A kinetic analysis of the regulation of the purified soluble enzyme by protoporphyrin IX, heme, and nitrosylheme. J Biol Chem 257:13312–13320 Wu P, Bao F, Zheng Q, Xiao N, Wang DT, Zeng QP (2012) Artemisinin and rapamycin compromise nitric oxide-driven and hypoxia-triggered acute articular synovitis in mice. Sci Sin Vitae 42:724-738 Xiao SH (2005) Development of antischistosomal drugs in China, with particular consideration to praziquantel and the artemisinins. Acta Trop 96:153–167 Yang RY, Feng LL, Yang XQ, Yin LL, Xu XL, Zeng QP (2008) Quantitative transcript profiling reveals downregulation of a sterol pathway relevant gene and overexpression of artemisinin biogenetic genes in transgenic Artemisia annua plants.

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