Athlete Performance and Injuries by Joao H. Bastos

By Joao H. Bastos

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2008). , 2006). , 2009a). , 2010). , 2007), and all of these factors are involved in the response to endurance exercise, this polymorphism in the MTS of MnSOD deserves to be further investigated in the context of improving performance, mainly among elite athletes of different modalities. 1 (OMIM*185490) and is the major SOD isoenzyme in extracellular fluids such as plasma, lymph, and synovial fluid, although it also occurs in tissues. , 2004). , 2005). , 2005). Although ECSOD provides important antioxidant defense against damage from free radicals, increased levels of this enzyme, such as those that occur in the polymorphism Arg213Gly, may in some cases lead to cell damage by an overproduction of H2O2, especially in individuals with a decreased capacity to remove this highly reactive compound by glutathione peroxidase or catalase.

Insulin-Like Growth Factor-1 (IGF-1) The somatomedins or insulin-like growth factors (IGFs) comprise a family of peptide hormones structurally related to insulin that play important roles in mammalian growth and development, having a pleiotropic effect on cell growth and metabolism. , 2011). , 1998; Haisma and Hon, 2006). , 2005). , 1998). , 2004). , 2007), polymorphisms in the IGF-1 gene which increase the hormone’s expression could favor performance of resistance training athletes. , 2002). , product of two or more genes, and their environment.

2004). , 2010). These contradictory results indicate the need to study cytokine haplotypes in association with studies involving elite and trained athletes, at least those involved in the systemic IL-6 response, such as IL-10, IL-1ra and TNF- receptor. 3. Methylenetetrahydrofolate Reductase (MTHFR) Gene Polymorphisms in the MTHFR gene have been reported in association with an altered plasma homocysteine (Hcy) level (Morita et al. 1997; van Bockxmeer et al. 1997; Fujimura et al. 2000; Miller et al.

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